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The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: a meta-analysis of individual patient data
When the peroxidation of a PLOOH molecule is not catalyzed by glutathione peroxidase 4 (GPX4) to form the corresponding alcohol (a PLOH), the PLOOH and lipid radicals, especially PLOO and alkoxy phospholipid radicals (PLO), continue to drive the dehydrogenation of PUFA-PLs and to react with oxygen through the Fenton reaction to generate a large number of PLOOH molecules [5, 15, 44, 45]
for the specific detection of GSH over Cys and Hcy 16
N-Acetyl Cysteine is widely used to control mucus hypersecretion, which can cause cough, sputum, and decline in lung function
Because SLC7A11 regulates GSH synthesis (through intracellular cystine availability) and 15LO1 decreases intracellular GSH, a high SLC7A11 to 15LO1 protein ratio likely supports high/normal intracellular GSH